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. Author manuscript; available in PMC: 2022 Dec 28.
Published in final edited form as: Nat Genet. 2022 Feb 3;54(2):170–179. doi: 10.1038/s41588-021-00993-x

Extended Data Fig. 7. 3D structure change induced by rs3824662 risk A allele.

Extended Data Fig. 7

a-b, HiC-based inference of chromosomal translocations in ALL PDX samples. In Patient #4, both inter-chromosomal (a) and intra-chromosomal translocation events (b) were inferred as showed by Hi-C heatmap. Upper panel of b showed the abnormal compartment state in chr7 in this patient. c, Genome browser snapshot of GATA3 biding at the MYC locus with T-ALL specific N-Me enhancer in GM12878 and ALL PDX samples. Blue bar indicates MYC gene as the bait for virtual 4C. Purple hollow bar indicates N-Me region.