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. Author manuscript; available in PMC: 2022 Dec 28.
Published in final edited form as: Nat Genet. 2022 Feb 3;54(2):170–179. doi: 10.1038/s41588-021-00993-x

Figure. 4. GATA3 expression leads to increased enhancer-promoter interaction, particularly in genes related to Ph-like ALL.

Figure. 4

a, APA plot indicates that GATA3 binding is enriched in engineered GM12878 (A/A) cell specific chromatin loops. b, Distance distribution of chromatin loops specific to GM12878 (A/A), GM12878 (WT), or common in both cell lines. c, Enhancer-Promoter and Promoter-Promoter are more enriched in the differential loops of engineered GM12878 (A/A) cells. d-e, Virtual 4-C analysis (40kb resolution) shows A/A genotype-specific chromatin looping between the P2RY8 enhancer (pink bar) and the CRLF2 promoter (yellow bar) in engineered GM12878 (A/A) cells and ALL PDX samples with A/A genotype. Red bar indicates the P2RY8 super enhancer predicted by ROSE.