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. Author manuscript; available in PMC: 2022 Dec 28.
Published in final edited form as: Nat Genet. 2022 Feb 3;54(2):170–179. doi: 10.1038/s41588-021-00993-x

Extended Data Fig. 1. Targeted GATA3 sequencing in 5,008 children with ALL and genomic features of the rs3824662 region.

Extended Data Fig. 1

a, Flow chart of Ph-like ALL risk variant discovery. GATA3 variants were identified from 5,008 children with ALL, of whom 995 patients were examined for Ph-like subtype (143 Ph-like vs. 852 non-Ph-like ALL). A total of 127 variants with sufficient frequency were subjected to association test in this subset. b, Read density and coverage of GATA3 targeted sequencing, including all open chromatin regions at this locus, based on ALL ATAC-Seq data, 3kb upstream of 5’UTR, and 1kb after 3’UTR. c, Multivariate analysis conditioning on rs3824662 revealed no independent signals for association with Ph-like ALL susceptibility at the GATA3 locus. d, rs3824662 WT C allele is ancestral to risk A alleles in 13 primates, using the EPO pipeline in ENSEMBL.