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. 2022 Dec 27;6:94. doi: 10.1038/s41698-022-00335-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Bar diagram displaying the number of reported hits per sample and in %. b Bar diagram depicting the report frequency (in %) of single drugs and drug classes. Color code integrated. c Unsupervised hierarchical clustering based on DSS_asym quantiles for the MDM2 inhibitors AMG-232 and idasanutlin. The color scale shown at the top represents quantile values. The TP53 status is highlighted with green (mutant) and white (wild-type) bars on the left side. d Pie diagrams reflecting the proportion of samples with reported hits with or without reported NGS (very) high-evidence targets for the total DSP cohort and different diagnoses.