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. 2022 Dec 27;6:94. doi: 10.1038/s41698-022-00335-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a Violin dot plots of case #2, a relapsed EWSR1:FLI1-positive Ewing sarcoma (EWS) before and after RIST therapy. The dot plots display the mean DSS_asym values for the whole cohort (left) and each drug for the respective sample before RIST treatment (middle) and after RIST treatment (right). The sample of interest before RIST is marked in orange, and the sample after RIST is marked in red. The blue line represents the mean. b Drug dot plots depicting the DSS_asym values for the indicated drugs for all successfully screened samples. The sample of interest before RIST is marked in orange, and the sample after RIST is marked in red. All four drugs displayed a strong decrease in DSS_asym after RIST therapy. c Violin dot plots of case #3, a relapsed CNS-HGNET brain tumor. Shown are DSP 1 and DSP 2 before and after MEMMAT therapy. The dot plots display the mean DSS_asym values for the whole cohort (left) and each drug for the respective case (DSP 1 in the middle; DSP 2 on the right). The sample of interest DSP1 before MEMMAT is marked in orange, and DSP2 after MEMMAT is marked in red. The blue line represents the mean. d Drug dot plots depicting the DSS_asym values for the single treatment (navitoclax or BCL-XL inhibitor A-1155463) and the combination (navitoclax plus dactinomycin or A-1155463 plus dactinomycin). The sample of interest (case #3, CNS-HGNET) is marked in orange. e Dose-response curves of a single compound (navitoclax) and combinatorial treatment (navitoclax plus IC₂₅ 10 nM dactinomycin). The overlay of both curves, reflecting a shift in sensitivity upon combinatorial treatment, is depicted. The combination screen was performed with cryopreserved cells cultured for four days after thawing for drug testing. % inhibition: normalized inhibition of metabolic activity.