Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Dec 27;12:22425. doi: 10.1038/s41598-022-23614-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

CHD8 binding at promoter of DE and ASD genes. (a) The odds ratio, strength, and significance of CHD8 binding on DEG promoters in heterozygous and homozygous CHD8 KO neurons (DE genes are obtained from RNA-seq experiment and odds ratio calculated based on overlapping gene list analysis) (GeneOverlap: http://shenlab-sinai.github.io/shenlab-sinai/). (b) Overlapping CHD8-bound genes in our experiment with genes that exhibit a recessive mutation in ASD and with previously published data set of CHD8 binding in human NPCs^48,49. Significance of the overlapping calculated with the hypergeometric test.