Table 2.
Interacting partners of KDM5A and KDM5B.
| Protein | Interacting partner | Function | Reference |
|---|---|---|---|
| KDM5A | NRa (e.g., ERb, ARc) | NR-mediated transcription | 132 |
| p50 | NK-cell activity | 133 | |
| PRC2d (Suz12) | Regulation of developmental genes | 134 | |
| NuRDe complex | 135 | ||
| SIN3Bf-HDACg | |||
| Retinoblastoma (RB) | Cellular senescence | 136 | |
| TBPh | Early development | ||
| p107 | Tumorigenesis | ||
| Rhombotin-2 | T-cell leukemogenesis | 137 | |
| KDM5B | PIWIL4i | DNA methylation of retrotransposons | 138 |
| CBX4j | Transcriptional repression | 39 | |
| HDAC1 (NuRD complex) | 12 | ||
| Retinoblastoma (RB) | Cellular senescence | 139 | |
| PAX9k | Early embryonic development in mouse (craniofacial features, limbs, teeth, and thymus) | 140 | |
| FOXG1bl (BF-1) | Early embryonic development in mouse (brain) | ||
| NR (e.g., ER, AR) | Tumorigenesis | 70,89 | |
| HDAC4 | Differentiation of mouse mammary glands and breast cancer development | 73 |
aNR nuclear receptor.
bER estrogen receptor.
cAR androgen receptor.
dPRC2 polycomb repressive complex 2.
eNuRD nucleosome remodeling deacetylase.
fSIN3B SIN3 transcription regulator family member B.
gHDAC histone deacetylase.
hTBP TATA-box-binding protein.
iPIWIL-4 Piwi-like protein 4.
jCBX4 chromobox 4.
kPAX9 paired Box 9.
lFOXG1b forkhead Box G1b.