FIG. 3.

Effect of CD8⁺ T-cell-mediated inflammation on surfactant activity in the lungs of P. carinii-infected mice. Average minimum surface tensions of the lavage fluid from immunocompetent, CD4⁺-depleted, and CD4⁺- and CD8⁺-depleted mice at 34 days after inoculation with P. carinii were measured. Lavage fluid and the LA surfactant fraction from immunocompetent, uninoculated mice were used as controls for surfactant activity. Minimum surface tension measurements were made with a pulsating-bubble surfactometer at 37°C during continuous cycling at a rate of 20 cycles/min. Each value is the mean ± 1 standard error.