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. 2022 Dec 27;6(3):e202201592. doi: 10.26508/lsa.202201592

Table 1.

Overview of experimental groups described in this study

Group name Tmc1 genotype Viral vector name Titer (vg/ml)
WT control +/+ None n/a
AAV2/9 eGFP +/+ AAV2/9.miSafe.eGFP 3.9 × 1013
AAV2/2 eGFP +/+ AAV2/2.miSafe.eGFP 4.2 × 1012
AAV2/2 eGFP w/WPRE +/+ AAV2/2.miSafe.eGFP.WPRE 5.8 × 1012
Bth/+ control Bth/+ None n/a
AAV2/9 replacement alone Bth/+ AAV2/9.miSafe.mTmc1 1.8× 1013
AAV2/9 RNAi + replacement Bth/+ AAV2/9.miTmc1D11.mTmc1 2.1 × 1013
AAV2/2 RNAi + replacement Bth/+ AAV2/2.miTmc1D11.mTmc1 4.0 × 1012
AAV2/2 RNAi + replacement w/WPRE Bth/+ AAV2/2.miTmc1D11.mTmc1.WPRE 4.8 × 1012
Bth/+ + AAV2/2 eGFP Bth/+ AAV2/2.miSafe.eGFP 4.2 × 1012

For readability, a shorthand description of each experimental group is used throughout this study.