Table 1.
Baseline demographic data of variables the UTUC patients.
| Variables | ≤ 90 days (N = 1181) | > 90 days (N = 70) | p-value a | ||
|---|---|---|---|---|---|
| N | % | N | % | ||
| Gender | |||||
| Men | 481 | (40.7) | 38 | (54.3) | 0.025* |
| Women | 700 | (59.4) | 32 | (45.8) | |
| Age | |||||
| <70 | 658 | (56.1) | 36 | (51.5) | 0.454 |
| ≥70 | 517 | (44.0) | 34 | (48.6) | |
| ECOG performance status | |||||
| 0 | 423 | (44.8) | 34 | (59.6) | 0.142 |
| 1 | 452 | (47.9) | 18 | (31.6) | |
| 2 | 58 | (6.1) | 5 | (8.8) | |
| CCI | |||||
| 0 | 285 | (24.1) | 18 | (25.7) | 0.764 |
| ≥1 | 896 | (75.9) | 52 | (74.3) | |
| Cell Type | |||||
| Urothelial | 1101 | (93.2) | 69 | (98.6) | 0.369 |
| Squamous | 3 | (0.3) | 0 | (0.0) | |
| UC with variants | 71 | (6.0) | 1 | (1.4) | |
| Others | 6 | (0.5) | 0 | (0.0) | |
| Tumor location | |||||
| Renal pelvis | 519 | (44.1) | 37 | (52.9) | 0.077 |
| Ureter | 444 | (37.8) | 17 | (24.4) | |
| Renal pelvis + Ureter | 215 | (18.4) | 16 | (23.0) | |
| Tumor size | |||||
| non-visible | 51 | (4.3) | 5 | (7.1) | 0.638 |
| <1cm | 111 | (9.4) | 8 | (11.4) | |
| ≥1 & < 2 cm | 292 | (24.8) | 14 | (20.0) | |
| ≥2 & < 3 cm | 273 | (23.2) | 14 | (20.0) | |
| ≥ 3cm | 449 | (38.3) | 29 | (41.5) | |
| Pathological stage T | |||||
| pTis | 19 | (1.6) | 3 | (4.3) | 0.370 |
| pTa | 194 | (16.9) | 16 | (23.3) | |
| pT1 | 352 | (30.4) | 20 | (29.0) | |
| pT2 | 265 | (22.9) | 12 | (17.4) | |
| pT3 | 314 | (27.3) | 17 | (24.7) | |
| pT4 | 12 | (1.0) | 1 | (1.4) | |
| Pathological stage N | |||||
| pN0 | 273 | (23.5) | 18 | (26.1) | 0.968 |
| pN1 | 16 | (1.4) | 1 | (1.4) | |
| pN2 | 19 | (1.6) | 1 | (1.4) | |
| pNx | 854 | (73.5) | 49 | (71.0) | |
| Adjuvant systemic therapy | |||||
| No | 979 | (82.9) | 59 | (84.3) | 0.764 |
| Yes | 202 | (17.2) | 11 | (15.8) | |
| Lymphovascular invasion | |||||
| No | 991 | (84.7) | 55 | (78.6) | 0.170 |
| Yes | 179 | (15.4) | 15 | (21.5) | |
| Surgical margin | |||||
| Free | 1136 | (98.0) | 67 | (97.2) | 0.642 |
| Positive | 24 | (2.1) | 2 | (2.9) | |
| Preoperative hydronephrosis | |||||
| No | 482 | (41.0) | 29 | (41.4) | 0.946 |
| Yes | 693 | (59.1) | 41 | (58.7) | |
| Mortality | |||||
| No | 734 | (62.2) | 41 | (58.6) | 0.716 |
| UTUC related | 98 | (8.3) | 5 | (7.1) | |
| non-UTUC related | 162 | (13.7) | 13 | (18.6) | |
| Unknown | 186 | (15.9) | 11 | (15.8) | |
| Disease free | |||||
| No | 187 | (15.9) | 14 | (20.1) | 0.352 |
| Yes | 927 | (78.6) | 50 | (71.5) | |
| Unknown | 67 | (5.7) | 6 | (8.6) | |
| Bladder UC after RNU | |||||
| No | 714 | (60.9) | 42 | (60.9) | 0.330 |
| Yes | 375 | (32.0) | 19 | (27.5) | |
| not available | 83 | (7.1) | 8 | (11.6) | |
| Follow up (months) b median | 59.8 | 54.5 | 0.717 | ||
ECOG, Eastern Cooperative Oncology Group; CCI, Charlson Comorbidity Index
a
Chi-Squared test calculated for the difference Variables.
b
Wilcoxon rank-sum test calculated for the difference in medians.
*< 0.05, ** < 0.01