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Role of Breg cells in preventing autoimmune reactions. In response to autoantigens, autoreactive B cells interact with T helper (Th) cells via TCR/MHC and CD40L/CD40, driving B cell differentiation into Breg cells. These IL-10-secreting Breg cells quell inflammatory responses by inhibiting APCs, increasing Treg cell activity, increasing invariant Natural Killer-like T (iNKT) cell numbers, and suppressing Th1 and Th17 cell activities.
