Table 2.
Comparison of the Ella biomarkers across TDA clusters.
| Variable | Plasma log10 pg/mg, median (IQR) | p-value* | |||
|---|---|---|---|---|---|
| Total | Cluster 1 | Cluster 2 | Cluster 3 | ||
| CRP | 6.75 (6.09, 7.62) | 7.33 (6.67, 7.98) | 6.43 (5.89, 7.11) | 6.29 (5.68, 7.13) | < 0.001 |
| CXCL10 | 2.17 (1.95, 2.37) | 2.28 (1.94, 2.53) | 2.1 (1.88, 2.28) | 2.19 (2.09, 2.51) | 0.02 |
| d-dimer | 5.69 (5.34, 6.23) | 6.06 (5.68, 6.85) | 5.49 (5.27, 5.87) | 5.68 (5.3, 6.52) | < 0.001 |
| Ferritin | 5.3 (4.98, 5.65) | 5.46 (5.07, 5.87) | 5.17 (4.82, 5.37) | 5.51 (5.31, 5.9) | < 0.001 |
| IFNγ | − 0.25 (− 0.45, 0) | − 0.3 (− 0.58, 0) | − 0.21 (− 0.39, 0) | − 0.27 (− 0.46, 0.02) | 0.11 |
| IL1Ra | 2.85 (2.56, 3.11) | 3.01 (2.84, 3.37) | 2.67 (2.5, 2.97) | 2.69 (2.4, 2.92) | < 0.001 |
| IL5 | − 0.56 (− 0.86, 0.34) | − 0.57 (− 0.95, − 0.4) | − 0.57 (− 0.81, − 0.31) | − 0.51 (− 0.85, − 0.24) | 0.69 |
| IL6 | 0.26 (0.01, 0.63) | 0.52 (0.24, 1.1) | 0.07 (− 0.13, 0.43) | 0.26 (0.05, 0.6) | < 0.001 |
| Procalcitonin | 1.78 (1.63, 2) | 1.92 (1.7, 2.25) | 1.69 (1.59, 1.86) | 1.92 (1.77, 2.1) | < 0.001 |
| RAGE | 2.93 (2.78, 3.04) | 2.76 (2.58, 2.87) | 3.02 (2.92, 3.09) | 3 (2.8, 3.07) | < 0.001 |
| TNFR1 | 3.03 (2.95, 3.18) | 3.15 (3.01, 3.3) | 2.98 (2.91, 3.08) | 3.04 (2.97, 3.16) | < 0.001 |
| VEGFA | 1.64 (1.43, 1.92) | 1.9 (1.57, 2.12) | 1.58 (1.43, 1.76) | 1.25 (0.8, 1.52) | < 0.001 |
For each subject, one sample was selected based on highest coefficient of variation.
*Distributions among all clusters compared using a Kruskal–Wallis test.
Significant values are in bold.