Figure 2.

Literature metrics. (a) 583 primary research items form the duocarmycin literature database reviewed here. Charts show the major research groups (>20 publications) and journals (>10 publications). (b) The literature was grouped as: (a) natural products, biochemistry, and molecular mechanism of CC-1065 and close analogues; (b) initial clinical trial compounds; then the focus groups of this Perspective: (1) synthetic analogues and SAR; (2) prodrugs and bifunctional conjugates; (3) ADCs. Group histograms reveal the chronological progress of duocarmycin research. Paper/patent ratios may indicate perceived commercialisation chances.