Table 3.
Hepatitis B status of all child participants and characteristics of children with chronic hepatitis B and children who were immune by exposure
| Hepatitis B status of child participants with complete serologya | ||||||||
| Status | Number (n = 33) | % (95% CI) | ||||||
| Immune by vaccination | 12 | 36.4 (20.4–54.9) | ||||||
| Immune by exposure | 3 | 9.1 (1.9–24.3) | ||||||
| Chronic hepatitis B infection | 3 | 9.1 (1.9–24.3) | ||||||
| Isolated anti-HBc positive | 2 | 6.1 (0.7–20.2) | ||||||
| Non-immune | 13 | 39.4 (22.9–57.9) | ||||||
| Characteristics of children with chronic hepatitis B (1–3) and children who were immune by exposure (4–8) | ||||||||
| Child | Gender | Gestational Age (weeks) | Weight (kg) | Mode of delivery | Mother’s age at time of birth | Fully vaccinatedb | HBIg documented as given at birth | Transmission |
| 1c | Female | 35 | 2.2 | Vaginal | 24.9 | No | Yes | Vertical (WGS) |
| 2 | Female | 34 | 1.8 | Vaginal | 17.4 | Yes | Yes | ? |
| 3 | Male | 32 | 1.4 | Vaginal | 21.9 | Yes | Yes | ? |
| 4 | Female | 35 | 2.2 | Vaginal | 24.9 | No | Yes | ? |
| 5d | Female | No details | No details | No details | 32.6 | Yes | Yes | Horizontal |
| 6d | Female | 38 | 3.5 | Vaginal | 27.6 | No | Yes | ? |
| 7 | Female | 40 | 3.6 | Vaginal | 21.1 | No | No | ? |
| 8 | Female | 39 | 2.6 | Caesarean | 32.3 | No | Yes | ? |
aOf the remaining 5 without complete serology, 2 had no serology, 1 had anti-HBc and anti-HBs performed only (and was anti-HBs positive, cAb negative), 1 had anti-HBs done only (positive), and 1 had HBsAg and anti-HBs done only (HBsAg negative, sAb positive)
bbirth dose given and three vaccines prior to 12 months of age given at appropriate intervals
cchild’s virus isolate whole genome sequenced
disolated core antibody positive