Table 2.

Review of reported molecular alterations of IOPN

References	Upregulated gene	Fusion	Loss of heterozygosity	Amplification	Gene mutation	Origin
Xiao et al. [10]					KRAS, BRAF	Pancreas
Mohri et al. [11]					KRAS	Pancreas
Schlitter et al. [12]			P16			Bile Duct
Amato et al. [6]					GNAS, KRAS	Pancreas
Basturk et al. [13]					ARHGAP26, ASXL1, EPHA8, ERBB4	Pancreas
Singhi et al. [5]		ATP1B1-PRKACA, ATP1B1-PRKACB, DNAJB1-PRKACA				Pancreas, Bile Duct
Vyas et al. [18]		DNAJB1-PRKACA, PRKACA-ATP1B1				Pancreas, Bile Duct
Aoki et al. [14]					TP53, KRAS, PBRM1, ELF3, NF1, BAP1, EPHA6, ERBB3, KMT2D, CDKN2A	Bile Duct
Nakahodo et al. [15]	Follistatin (FST)					Pancreas, Bile Duct
Chang et al. [16]					KRAS	Pancreas
Omori et al. [8]			P16		STK11, KRAS, P53, SMAD4	Pancreas
Maimaitiaili et al. [17]		ATP1B1-PRKACA, DNAJB1-PRKACA ATP1B1-PRKACB			KRAS	Pancreas, Bile Duct
This case				EGFR	STK11, GNAS	Bile Duct