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. 2022 Dec 28;20:626. doi: 10.1186/s12967-022-03818-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — MiR-4443 was upregulated in radioresistant ESCC cells. A Clonogenic survival assays were conducted using KYSE-150R and parental KYSE-150 cells to evaluate the radioresistance of KYSE-150R. B Survival curves of KYSE-150R cells and KYSE-150 cells were calculated and fitted to a multitarget model. C The expression profiles of miR-4443 in GSE43732 (Adjacent, n = 119; Cancer, n = 119). D qRT-PCR for miR-4443 in 3 esophageal squamous cell carcinoma cell lines and 1 normal esophageal cell line. E qRT-PCR for miR-4443 in parental cells and radioresistant cells. F qRT-PCR analysis of miR-4443 expression in ESCC cells treated with different doses of radiation. Data are shown as the mean ± SD from three independent experiments. (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)