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. 2022 Dec 28;20:626. doi: 10.1186/s12967-022-03818-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Knockdown of miR-4443 enhanced the radiosensitivity of ESCC cells. A–C Representative immunofluorescence images of nuclear γ-H2AX foci (cell nuclei: blue; γ-H2AX foci: green) in the indicated cells after 24 h of 8 Gy radiation. Scale bar: 4 µm. D–F Western blot analysis of γ-H2AX protein expression levels in the indicated cells after 24 h of 8 Gy radiation. G–I Evaluation of the apoptosis rates of ESCC cells with altered expression levels of miR-4443. J, K Cell cycle distribution in the indicated cells after 6 h of 8 Gy radiation. Data are presented as the mean ± SD; n = 3 independent experiments. (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)