Table 3.

Reasons Off Treatment by Total Number of Treatment Cycles Given

Off Treatment Reason	Total Number of Cycles Given
	1	2	3	4	6	10	Total
	N	N	N	N	N	N	N	%
Adverse event/side effects/complications	1	1	1	0	0	0	3	25.0
Death on study	0	1	0	0	0	0	1	8.3
Disease progression- relapse during active treatment	0	0	0	1	1	2	4	33.3
Patient withdrawal/refusal after beginning protocol therapy	0	0	1	1	0	0	2	16.7
Other	1a	0	1b	0	0	0	2	16.7
Total	2	2	3	2	1	2	12	100.0

^aOff treatment for medical decision

^boff treatment due to symptoms demonstrating disease progression and/or intolerance of sapanisertib