Table 1.
Summary of single component effects on maturation main hallmarks
| Component | Metabolism | Cellular structure | Electrophysiology | ||||
|---|---|---|---|---|---|---|---|
| Mitochondria | FAO | Stress test | Contractile apparatus | Polyploidism | Ion channels | Contraction | |
| AA |
↑ organization ↑ ATP synthesis |
↑ lactate metabolism ↑ recovery and substrate switch |
↑↑ basal respiration ↑ ATP production |
↑ sarcomere | ↑ > 4N |
↑ gap junction ↑ potassium ↑ sodium ↑ calcium |
↑ rise time ↑ CTD25 ↑ FWHM ↑ CTD75 ↑ decay time |
| GW |
↑ organization ↑ activity ↑ ATP synthesis |
↑ FAO metabolism ↑ proton leak |
↑↑ sarcomere |
↑↑ gap junction ↑ potassium ↑ sodium ↑ calcium |
↑ rise time ↑ CTD25 ↑ FWHM ↑ decay time |
||
| T3 |
↑ organization ↑ activity |
↑ lactate metabolism ↑ FAO metabolism |
↑ sarcomere |
↑↑ gap junction ↑ potassium ↑ sodium ↑ calcium |
|||
Bold text indicates protein content