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. 2022 Dec 27;20:498. doi: 10.1186/s12916-022-02708-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Total pathological complete response (tpCR) rate and breast pathological complete response (bpCR) rate. A Per independent central review; B per local pathology review. Patients with missing or unevaluable pCR status were considered non-responders. Error bars show 95% CIs for the pCR rate in each group, which were calculated using the Wilson method. Comparison between groups was done using the Cochran-Mantel-Haenszel test stratified by the randomization strata, and the 95% CI for the between-group difference was calculated using the Wald method