Fig. 3.

12 years old male patient from poor-response group, with osteosarcoma of 554 cc volume in left tibia and multiple metastatic lung nodules at baseline. Patient had 35% histological necrosis in resected tumor specimen and event free survival and overall survival of 16.3 months. 1st, 2nd and 3rd columns show images at time points t0 (baseline), t1 (after 1st cycle of chemotherapy) and t2 (after completion of chemotherapy) respectively and 4th column represents histograms of parametric maps in tumor volume at three time-points t0 (green), t1 (orange) and t2 (blue). a, b T2-weighted fat saturated image, c–e DWI (b = 800 s/mm²), f–h Apparent diffusion coefficient (ADC), i Histogram of ADC was high peaked and sharp at t0 and slightly shifted to the right of the coordinate and became sharply peaked at t1 and t2. j–l Diffusion coefficient (D), m Histogram of D was high peaked and sharp at t0 and slightly shifted to the right of the coordinate and became sharply peaked at t1 and t2. n–p Perfusion coefficient (D*), q Histogram of D* was positively skewed with a heavy tail at t0, became highly peaked at t1 and turned to a wider & flat (low peaked) shape at t2. r–t Perfusion fraction (f), u Histogram of f was wide and low peaked at t0, became slightly positively skewed and high peaked at t1 and t2. v–x D*.f, y Histogram of D*.f was low peaked with long tail at t0 and became high peaked at t1 and more positively skewed at t2