Table 2.

Average Apparent Diffusion Coefficient (ADC), Diffusion coefficient (D), Perfusion Coefficient (D*), Perfusion fraction (f) and D*.f in good-response (GR) and poor-response (PR) groups at baseline (t0), after 1st cycle of chemotherapy (t1), and after 3rd cycle of chemotherapy (t2) and the relative percentage changes of parameters across time-points t0 & t1 (ΔI) and t0 & t2 (ΔII)

Parameters	GR (n = 13)	PR (n = 22)	p-value
Time-point t0
ADC (× 10−3 mm2/s)	1.30 ± 0.29*#	1.41 ± 0.36*#	0.36
D (× 10−3 mm2/s)	1.21 ± 0.28*#	1.35 ± 0.32*#	0.20
D* (× 10−3 mm2/s)	23.76 ± 7.56#	30.95 ± 10.80#	0.04
f (%)	13.31 ± 2.68	14.05 ± 2.99	0.47
D*.f × 10−3 mm2/s	3.85 ± 1.90#	5.12 ± 2.52#	0.13
Time-point t1
ADC (× 10−3 mm2/s)	1.53 ± 0.28*	1.68 ± 0.29*	0.04
D (× 10−3mm2/s)	1.44 ± 0.35*	1.66 ± 0.27*	0.02
D* (× 10−3mm2/s)	19.77 ± 4.20	25.32 ± 12.47	0.13
f (%)	13.36 ± 2.04	12.89 ± 2.69	0.59
D*.f (× 10−3mm2/s)	2.97 ± 1.02	4.49 ± 2.32	0.01
ADC-ΔI (%)	20.08 ± 20.24	29.00 ± 31.17	0.36
D-ΔI (%)	21.63 ± 27.15	28.68 ± 28.12	0.47
D*-ΔI (%)	− 14.86 ± 26.63	− 10.45 ± 50.66	0.63
f-ΔI (%)	3.15 ± 20.28	− 5.56 ± 21.42	0.24
D*.f-ΔI (%)	− 12.12 ± 34.90	− 4.90 ± 39.22	0.59
Time-point t2
ADC (× 10−3 mm2/s)	1.66 ± 0.21#	1.75 ± 0.30#	0.35
D (× 10−3 mm2/s)	1.57 ± 0.20#	1.66 ± 0.27#	0.29
D* (× 10−3 mm2/s)	17.77 ± 6.02#	23.44 ± 10.65#	0.09
f (%)	12.55 ± 1.24	13.22 ± 2.54	0.38
D*.f (× 10−3 mm2/s)	2.53 ± 1.37#	3.50 ± 1.86#	0.11
ADC-ΔII (%)	31.35 ± 21.99	30.01 ± 33.74	0.90
D-ΔII (%)	33.08 ± 18.73	27.60 ± 29.48	0.55
D*-ΔII (%)	− 22.12 ± 29.97	− 19.98 ± 31.83	0.79
f-ΔII (%)	− 2.16 ± 21.90	− 2.74 ± 23.86	0.94
D*.f-ΔII (%)	− 26.64 ± 49.64	− 23.73 ± 30.44	0.83

p-values are showing statistical significance of parameters between GR and PR groups using independent sample t test

^* Significantly change (p < 0.05) according to paired t-test between time point t0 and t1

^# Significantly change (p < 0.05) according to paired t-test between time point t0 and t2