Table 3.

Statistically significant (independent sample t test, p < 0.05) histogram parameters of ADC, D, D*, f and D*.f among good-response and poor-response groups at baseline (time-points t0) and after 1st cycle of chemotherapy (time-point t1) and their ROC curve analysis for predicting poor-response to chemotherapy

Time-point	Parameters	t test, p value	Sensitivity (%)	Specificity (%)	Cut-off Value	AUC (95% CI)
t0	ADC-Mean	0.36	55	67	> 1.36	0.61 (0.42–0.80)
	D-Mean	0.20	65	67	> 1.2	0.66 (0.47–0.85)
	D*-Mean	0.04	65	75	> 26.9	0.70 (0.52–0.87)
	f-Mean	0.47	75	50	> 12.04	0.57 (0.37–0.77)
	D*.f-Mean	0.13	65	67	> 3.95	0.67 (0.48–0.86)
	Mean ADC, D, D*, f, D*.f combined		77	77	< 0.58	0.77 (0.62–0.93)
	D*-skewness	0.04	71	67	< 0.27	0.7 (0.52–0.88)
	D*-entropy	0.04	68	69	> 8.72	0.7 (0.52–0.88)
	D*-90th percentile	0.03	77	62	> 64.68	0.72 (0.54–0.9)
	D*-75th percentile	0.04	76	57	> 36.05	0.7 (0.52–0.88)
	f-entropy	0.04	77	62	> 8.77	0.65 (0.46–0.85)
	D*.f-entropy	0.03	68	69	> 7.1	0.72 (0.53–0.9)
	All Combined		86	77	< 0.66	0.87 (0.68–0.99)
t1	ADC-mean	0.04	60	77	> 1.72	0.71 (0.57–0.9)
	D-mean	0.02	68	70	> 1.62	0.73 (0.54–0.89)
	D*-mean	0.13	64	77	> 21.33	0.65 (0.46–0.83)
	f-mean	0.59	60	58	> 12.32	0.61 (0.42–0.80)
	D*.f-mean	0.01	77	77	> 3.14	0.76 (0.59–0.92)
	Mean ADC, D, D*, f, D*.f combined		91	85	> 0.55	0.92 (0.82–1)
	ADC-90th percentile	0.03	68	77	> 2.26	0.72 (0.54–0.89)
	D-90th percentile	0.01	73	85	> 2.17	0.76 (0.59–0.92)
	D-75th percentile	0.03	64	77	> 1.94	0.72 (0.56–0.89)
	D-60th percentile	0.04	64	62	> 1.77	0.70 (0.53–0.88)
	D-50th percentile	0.04	55	62	> 1.68	0.70 (0.53–0.88)
	D-25th percentile	0.03	55	69	> 1.36	0.71 (0.53–0.89)
	All Combined		86	100	> 0.60	0.96 (0.89–1)

SD: Standard deviation; ROC: Receiver Operating Characteristics Curve; AUC: Area under the Curve; CI: confidence interval

ADC: × 10⁻³ mm²/s D: × 10⁻³ mm²/s; D*: × 10⁻³  mm²/s; f: %. D*.f: × 10⁻³mm²/s