Table 4.
Clinical and imaging parameters from univariate and multivariate Cox regression analysis that have statistically significant (p < 0.05) association with the event free survival (EFS) and overall survival (OS) in patients with osteosarcoma (n = 35)
| EFS (n = 35) | OS (n = 35) | ||||
|---|---|---|---|---|---|
| Parameters | HR (95% CI) | p value | Parameters | HR (95% CI) | p value |
| Univariate analysis | |||||
| Clinical parameter | Clinical parameter | ||||
| Metastasis | 2.9 (1.2–6.6) | 0.013 | Metastasis | 5.4 (2.1–14) | < 10–3 |
| ALP | 1 (0.99–1.001) | 0.005 | ALP | 1 (0.99–1.002) | 0.002 |
| Tumour-volume | 1 (0.99–1.01) | 0.011 | Volume | 1 (0.99–1.002) | 0.013 |
| Imaging parameter | Imaging parameter | ||||
| ADC-Mean | 0.14 (0.028–0.74) | 0.02 | D*-Mean | 1.1 (1–1.1) | 0.009 |
| ADC-90th percentile | 0.27 (0.075–0.96) | 0.043 | D*-skewness | 0.41 (0.2–0.83) | 0.014 |
| ADC-75th percentile | 0.22 (0.06–0.84) | 0.026 | D*-90th percentile | 1.1 (1–1.1) | 0.032 |
| ADC-60th percentile | 0.21 (0.051–0.86) | 0.03 | D*-75th percentile | 1 (1–1.1) | 0.017 |
| ADC-50th percentile | 0.19 (0.042–0.87) | 0.033 | D*-60th percentile | 1 (1–1.1) | 0.013 |
| ADC-25th percentile | 0.11 (0.017–0.7) | 0.019 | D*-50th percentile | 1 (1–1.1) | 0.010 |
| D-Mean | 0.12 (0.019–0.79) | 0.027 | D*-25th percentile | 1.1 (1–1.1) | 0.023 |
| D-90th percentile | 0.17 (0.035–0.84) | 0.03 | D*.f-skewness | 0.56 (0.34–0.94) | 0.028 |
| D-75th percentile | 0.19 (0.04–0.88) | 0.034 | D*.f-kurtosis | 0.93 (0.87–1) | 0.045 |
| D-60th percentile | 0.19 (0.038–0.96) | 0.044 | D*.f-entropy | 1.8 (1–3) | 0.033 |
| D-50th percentile | 0.18 (0.034–0.99) | 0.049 | D*.f-60th percentile | 1.2 (1–1.3) | 0.042 |
| D-25th percentile | 0.18 (0.041–0.82) | 0.026 | D*.f-50th percentile | 1.2 (1–1.4) | 0.030 |
| D*-Mean | 1.1 (1–1.1) | 0.004 | D*.f-25th percentile | 1.6 (1.1–2.3) | 0.021 |
| D*-skewness | 0.37 (0.18–0.76) | 0.007 | – | ||
| D*-75th percentile | 1 (1–1.1) | 0.013 | – | ||
| D*-60th percentile | 1 (1–1.1) | 0.007 | – | ||
| D*-50th percentile | 1 (1–1.1) | 0.004 | – | ||
| D*-25th percentile | 1.1 (1–1.2) | 0.001 | – | ||
| D*.f-60th percentile | 1.2 (1–1.3) | 0.032 | – | ||
| D*.f-50th percentile | 1.2 (1–1.5) | 0.015 | – | ||
| D*.f-25th percentile | 2 (1.3–3.1) | 0.002 | – | ||
| Multivariate analysis | |||||
| EFS-Model-1 | OS-Model-1 | ||||
| Tumour-volume | 1.002 (1.001–1.003) | 0.001 | Metastasis | 4.330 (1.638–11.449) | < 10–3 |
| ADC-25th percentile | 0.047 (0.006–0.394) | 0.005 | D*-Mean | 1.045 (0.999–1.093) | 0.056 |
| EFS-Model-2 | OS-Model-2 | ||||
| Tumour-volume | 1.001 (1–1.003) | 0.007 | Metastasis | 2.955 (1.021–8.554) | 0.046 |
| D-Mean | 0.1 (0.014–0.726) | 0.023 | Tumour-volume | 1.001 (1–1.003) | 0.042 |
| D*-Mean | 1.052 (1.003–1.103) | 0.039 | D*.f-skewness | 0.544 (0.298–0.995) | 0.048 |