Fig. 1.

Proportion of patients with clinically relevant global or selective cognitive impairments in comparison with (A) normative scores adjusted for age, sex and education estimated with regression models and with (B) an age-, sex- and education-matched healthy control group (n = 150). Cut-off for global impairment defined as ≥1 SD below estimated expected score in (A) and ≥1 SD below the normative mean from the healthy control group in (B). Cut-off for selective impairment defined as ≥1 SD below estimated expected score or ≥1 SD below the HC mean on ≥2 of the six cognitive tests in comparison with group A or B, respectively. One of the 194 patients excluded from this analysis due to one incomplete subtest and consequently no SCIP total score; the analysis was thus conducted based on n = 193 patients.