Table 4.

Pharmacologic Therapies for POTS With Pregnancy and Breastfeeding Classification

Medication	FDA Pregnancy Category	Excreted in Milk	Common Side Effects
Propranolol	C	Yes	Bradycardia, hypotension, depression
Metoprolol	C	Yes	Bradycardia, fatigue, headache
Labetalol	C	Yes	Fatigue, headache, dizziness, nausea
Ivabradine	D	Unknown	Bradycardia, dizziness, visual disturbance
Fludrocortisone	C	Unknown	Hypokalaemia, hypertension, headache
Midodrine	C	Unknown	Paresthesia, scalp itching, piloerection, supine hypertension
Pyridostigmine	B	Yes	Nausea, diarrhoea, urinary frequency, abdominal pain
Clonidine	C	Yes	Dizziness, dry mouth, fatigue