Table 1.

The Hanifin and Rajka diagnostic criteria for atopic dermatitis.

Major criteria (≥ 3 required)		Minor criteria (≥ 3 required)
1	Pruritus	1	Xerosis
2	Typical morphology and distribution:	2	Ichthyosis, palmar hyperlinearity, or keratosis pilaris
	Flexural lichenification or linearity in adults	3	Immediate (type 1) skin‐test reactivity
	Facial and extensor involvement in infants and children	4	Raised serum IgE
3	Chronic or chronically relapsing dermatitis	5	Early age of onset
4	Personal or family history of atopy (asthma, allergic rhinitis, atopic dermatitis)	6	Tendency toward cutaneous infections (especially Staphylococcus aureus and herpes simplex) or impaired cell‐mediated immunity
		7	Tendency toward nonspecific hand or foot dermatitis
		8	Nipple eczema
		9	Cheilitis
		10	Recurrent conjunctivitis
		11	Dennie–Morgan infraorbital fold
		12	Keratoconus
		13	Anterior subcapsular cataracts
		14	Orbital darkening
		15	Facial pallor or facial erythema
		16	Pityriasis alba
		17	Anterior neck folds
		18	Itch when sweating
		19	Intolerance to wool and lipid solvents
		20	Perifollicular accentuation
		21	Food intolerance
		22	Course influenced by environmental or emotional factors
		23	White dermographism or delayed blanch