TABLE 2.
Results of quantitative analysis of c‐Fos and pS6 labeling in STG, pulvinar, and insular regions
| Region | SUDEP | Definite SUDEP | Epilepsy controls | Nonepilepsy controls | |
|---|---|---|---|---|---|
|
c‐Fos Neuronal density/mm2, mean (SD) (N = cases a ) Percentage positive neurons (SD) |
STG |
348.43 (260) N = 19 52.3% (26) |
279.9 (172.1) N = 15 48.9% (25) |
408.15 (285.5) N = 7 48.9% (26) |
298.49 (193.3) N = 18 48.2% (25) |
| Insular |
277.9 (245) N = 19 37.7% (24) |
287.18 (249.4) N = 18 38.6% (25) |
325.0 (137.8) N = 7 41.5% (10) |
174.57 (164.05) N = 8 26.8% (19.7) |
|
| Pulvinar |
49.05 (61.8) N = 19 7.6% (7) |
40.56 (42.7) N = 17 6.9% (6.2) |
24.2 (2.9) N = 3 6.5% (1.5) |
47.49 (54.87) N = 8 8.8% (10.5) |
|
|
pS6‐240/4 (N = cases a ) Neuronal density/mm2, mean (SD) Percentage positive neurons (SD) |
STG |
28 (40)/mm2 N = 15 6.6% (8) |
18 (32)/mm2 N = 13 7% (9.2) |
1 (2)/mm2 N = 6 6.6% (2.9) |
6 (10)/mm2 N = 18 1.2% (.53) |
| Insular |
5 (14)/mm2 N = 18 3.9% (4.7) |
6 (15)/mm2 N = 15 4.1% (5.1) |
0.8 (0.5)/mm2 N = 8 3.5% (2) |
0.7 (0.7)/mm2 N = 7 2.1% (1.6) |
|
| Pulvinar |
5 (10)/mm2 N = 17 6.9% (8.7) |
6 (11)/mm2 N = 15 7.2% (9.1) |
0.1 (0.05)/mm2 N = 3 3% (1.8) |
0.2 (0.1)/mm2 N = 8 2.6% (3.5) |
|
|
pS6‐235/6 (N = cases a ) Labeling index (%), mean (SD) |
STG |
0.26 (0.35) N = 19 |
0.31 (0.37) N = 15 |
0.075 (0.08) N = 6 |
0.071 (0.06) N = 18 |
| Insular |
0.13 (0.15) N = 11 |
0.13 (0.16) N = 10 |
0.086 (0.1) N = 3 |
0.084 (0.1) N = 5 |
|
| Pulvinar |
0.76 (0.88) N = 16 |
0.65 (0.8) N = 14 |
0.67 (0.3) N = 5 |
0.98 (0.59) N = 7 |
Refers to the number of cases evaluated in each group for each region (not all regions were available in all cases).