TABLE 1.

Summary of primary composite chronic kidney disease endpoint

Components of primary composite CKD outcome		Definition
Sustained percent decline in eGFR		Percent decline in eGFR of ≥40% from baseline and sustained over at least 4 weeks
ESKD	Kidney transplantation	Receipt of a kidney transplant
	Maintenance dialysis	Dialysis performed for at least 4 weeks
	Sustained low eGFR	eGFR < 15 mL/min per 1.73 m2 sustained over at least 4 weeks
	Diagnosis at primary care	Diagnosis of CKD stage 5: eGFR<15 mL/min per 1.73 m2
Kidney death		Death with chronic kidney disease as the underlying cause of death

Abbreviations: CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; ESKD, end‐stage kidney disease.