TABLE 2.
Selected enriched biology pathways identified using all of the genes in the SAGAS database
| Pathway | FDR |
|---|---|
| L1CAM interactions | 7.8 × 10−26 |
| Asparagine N‐linked glycosylation | 4.0 × 10−17 |
| NCAM signaling for neurite out growth | 1.1 × 10−14 |
| Signaling by NTRKS | 1.1 × 10−14 |
| CREB1 phosphorylation through NMDA receptor‐mediated activation of RAS signaling | 8.0 × 10−14 |
| Interaction between L1 and ankyrins | 1.5 × 10−13 |
| MAPK family signaling cascades | 2.5 × 10−12 |
| Citric acid TCA cycle and respiratory electron transport | 3.0 × 10−12 |
| G alpha (i) signaling events | 3.0 × 10−11 |
| Signaling by VEGF | 3.2 × 10−11 |
| RAS activation upon CA2 influx through NMDA receptor | 2.5 × 10−10 |
| Synthesis of glycosylphosphatidylinositol | 3.6 × 10−10 |
| PI3K AKT signaling in cancer | 3.9 × 10−10 |
| Signaling by PDGF | 5.5 × 10−10 |
| Regulation of MECP2 expression and activity | 7.9 × 10−10 |
Note: The complete list of enriched biological pathways can be found in Tables S1–S5.
Abbreviations: FDR, false discovery rate; SAGAS, Seizure‐Associated Genes Across Species.