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. 2022 Jul 26;37(10):2021–2032. doi: 10.1002/mds.29168

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© 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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FIG 4 — Manifest YAC128 mice: performance and striatal activity during rotarod. (A) Latency to fall over days of training for manifest YAC128 compared with WT (genotype, P < 0.0001; time, P < 0.0001; multiple comparisons: day 1, P = 0.0072, denoted by **; day 2, P < 0.0001, denoted by ****; day 3, P = 0.0001, denoted by ***; day 4, P < 0.0001, denoted by ****). (B) Percentage of trials where mice fell, rotated, or completed the full duration. (C) Paw slips during the first 10 seconds for WT and manifest YAC128 over days of training (genotype, P < 0.0001; day, P = 0.0021; multiple comparisons: day 1, P = 0.0335, denoted by *, day 2, P = 0.0034, denoted by **). (D) Right and left paw heights over days of training (genotype, P < 0.0001 both paws; day: right paw, P = 0.0035; left paw, P < 0.0001; multiple comparisons day 1: right, P = 0.0118, denoted by *, left, P = 0.0271, denoted by *; day 3: right, P = 0.0486, denoted by *). (E) SD of right and left paw height (genotype, P < 0.0001 both paws; day: right paw, P = 0.0104, left paw, P = 0.0128; multiple comparisons day 1: right, P = 0.0194, denoted by *, left, P = 0.0001, denoted by ***; day 2: right, P = 0.0034, denoted by **, left, P = 0.0255, denoted by *; day 3: right, P = 0.0342, denoted by *, left, P = 0.0028, denoted by **; day 4: left, P = 0.0233, denoted by *). (F) Latency to fall for WT, and YAC128 GP and PP (group, P < 0.0001; day, P < 0.0001; interaction, P = 0.0030). (G) Left: Mean z score on rotarod over days of training in WT and GP YAC128 (genotype, P = 0.0079; day, P < 0.0001). Right: Examples from one WT and one GP YAC128 showing jGCaMP7f traces (three trials averaged) on day 1 (top) and day 4 (bottom). Gray areas denote approximate times when mice are on the rotarod based on daily mean latency to fall (YAC128, dark gray; WT, light gray). Dotted lines indicate mean latency to fall of the three trials (YAC128, red; WT, black). GP, good performers; PP, poor performers; SD, standard deviation; WT, wild type; YAC128, yeast artificial chromsome‐128CAG. [Color figure can be viewed at wileyonlinelibrary.com]