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. 2022 Nov 23;15(11):dmm049871. doi: 10.1242/dmm.049871

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© 2022. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Extracellular vesicular structure connected to inner segment mitochondrion through a complex membrane tunnel. (A) Representative z-sections at the depths of 0, +14, +28 and +42 nm obtained from a 3D electron tomogram of a 250 nm-thick WT mouse retinal section stained with tannic acid/uranyl acetate. Full tomogram is shown in Movie 4. Arrowheads depict a membrane tunnel connecting the budding vesicle with an inner segment mitochondrion. Tomogram pixel size is 1.4 nm; scale bar: 0.2 µm. (B) The corresponding 3D segmentation in two views: from the top as in A and from the bottom. Full segmentation is shown in Movie 6. IMM, inner mitochondrial membrane (blue); Mito, mitochondrion; OMM, outer mitochondrial membrane (green); PM, plasma membrane (red). The data are selected from a total of 12 tomograms documenting extracellular vesicular structures connected to mitochondrial membranes obtained from three WT mice.