Table 4.
Results of multiple linear regression analyses for assessing the relationships between stratified spouse bereavement and Aβ, AV‐1451, AD‐CM, AD‐CT, HVa, or WBV (N = 118)
| No spouse bereavement | Spouse bereavement | ||
|---|---|---|---|
| n = 59 | |||
| n = 59 | |||
| B (95% CI) | P‐value | ||
| Aβ retention, SUVR | |||
| Model I † | Reference | −0.049 (−0.130 to 0.032) | 0.231 |
| Model II ‡ | Reference | −0.030 (−0.094 to 0.035) | 0.366 |
| Model III § | Reference | −0.025 (−0.092 to 0.041) | 0.456 |
| AV‐1451, SUVR | |||
| Model I † | Reference | −0.204 (−0.717 to 0.308) | 0.420 |
| Model II ‡ | Reference | −0.181 (−0.720 to 0.359) | 0.493 |
| Model III § | Reference | 0.053 (−0.563 to 0.669) | 0.856 |
| AD‐CM, SUVR | |||
| Model I † | Reference | −0.011 (−0.064 to 0.041) | 0.664 |
| Model II ‡ | Reference | −0.021 (−0.070 to 0.029) | 0.411 |
| Model III § | Reference | −0.024 (−0.076 to 0.028) | 0.359 |
| AD‐CT, mm | |||
| Model I † | Reference | −0.026 (−0.105 to 0.053) | 0.518 |
| Model II ‡ | Reference | −0.044 (−0.117 to 0.029) | 0.233 |
| Model III § | Reference | −0.052 (−0.125 to 0.021) | 0.061 |
| HVa, cm3 | |||
| Model I † | Reference | −0.114 (−0.519 to 0.290) | 0.577 |
| Model II ‡ | Reference | −0.213 (−0.565 to 0.139) | 0.232 |
| Model III § | Reference | −0.284 (−0.634 to 0.067) | 0.111 |
| WBV | |||
| Model I † | Reference | 0.002 (−0.010 to 0.015) | 0.707 |
| Model II ‡ | Reference | 0.001 (−0.011 to 0.013) | 0.881 |
| Model III § | Reference | −0.002 (−0.014 to 0.010) | 0.775 |
Unadjusted.
Adjusted for clinical diagnosis, vascular risk score (VRS), body mass index (BMI), apolipoprotein ε4 (APOE4), and undernutrition.
Adjusted for clinical diagnosis, VRS, BMI, APOE4, undernutrition, education, occupational complex, annual income, Geriatric Depression Scale (GDS) score, Medical Outcomes Study‐Social Support Survey (MOS‐SSS) score, alcohol intake status, and smoking status.
Aβ, beta‐amyloid; AD‐CM, Alzheimer disease signature cerebral glucose metabolism; AD‐CT, Alzheimer disease signature cortical thickness; CI; confidence interval; HVa, adjusted hippocampal volume; SUVR, standardized uptake value ratio; WBV, whole brain volume.