Table 5.
Results of multiple linear regression analyses for assessing the relationships between stratified spouse bereavement and Aβ, AV‐1451, AD‐CM, AD‐CT, Hva, or WBV (N = 118)
| No spouse bereavement | Spouse bereavement at <60 years | Spouse bereavement at ≥60 years | |||
|---|---|---|---|---|---|
| n = 59 | |||||
| n = 29 | n = 30 | ||||
| B (95% CI) | P‐value | B (95% CI) | P‐value | ||
| Aβ retention, SUVR | |||||
| Model I † | Reference | −0.088 (−0.186 to 0.010) | 0.079 | −0.010 (−0.108 to 0.088) | 0.840 |
| Model II ‡ | Reference | −0.072 (−0.149 to 0.005) | 0.068 | 0.015 (−0.064 to 0.093) | 0.708 |
| Model III § | Reference | −0.074 (−0.156 to 0.007) | 0.074 | 0.020 (−0.059 to 0.099) | 0.624 |
| AV‐1451, SUVR | |||||
| Model I† | Reference | −0.265 (−0.992 to 0.461) | 0.459 | −0.174 (−0.754 to 0.407) | 0.544 |
| Model II ‡ | Reference | −0.431 (−1.214 to 0.353) | 0.265 | −0.069 (−0.668 to 0.529) | 0.811 |
| Model III § | Reference | −0.234 (−1.166 to 0.699) | 0.597 | 0.156 (−0.516 to 0.828) | 0.624 |
| AD‐CM, SUVR | |||||
| Model I † | Reference | −0.014 (−0.078 to 0.050) | 0.671 | −0.009 (−0.073 to 0.055) | 0.779 |
| Model II ‡ | Reference | −0.019 (−0.079 to 0.041) | 0.539 | −0.023 (−0.084 to 0.039) | 0.467 |
| Model III § | Reference | −0.021 (−0.085 to 0.044) | 0.530 | −0.027 (−0.090 to 0.035) | 0.390 |
| AD‐CT, mm | |||||
| Model I † | Reference | 0.006 (−0.092 to 0.105) | 0.899 | −0.056 (−0.152 to 0.040) | 0.251 |
| Model II ‡ | Reference | −0.008 (−0.098 to 0.081) | 0.856 | −0.080 (−0.168 to 0.009) | 0.079 |
| Model III § | Reference | −0.022 (−0.113 to 0.070) | 0.639 | −0.077 (−0.164 to 0.009) | 0.080 |
| HVa, mm3 | |||||
| Model I † | Reference | 0.146 (−0.396 to 0.689) | 0.594 | −0.237 (−0.773 to 0.299) | 0.382 |
| Model II‡ | Reference | −0.009 (−0.488 to 0.469) | 0.969 | −0.406 (−0.903 to 0.092) | 0.109 |
| Model III § | Reference | −0.066 (−0.554 to 0.422) | 0.789 | −0.483 (−0.971 to 0.006) | 0.053 |
| WBV | |||||
| Model I † | Reference | 0.001 (−0.014 to 0.017) | 0.850 | 0.003 (−0.012 to 0.018) | 0.678 |
| Model II ‡ | Reference | 0.001 (−0.015 to 0.016) | 0.928 | 0.001 (−0.014 to 0.016) | 0.879 |
| Model III § | Reference | −0.004 (−0.09 to 0.012) | 0.652 | <0.001 (−0.015 to 0.014) | 0.971 |
Unadjusted.
Adjusted for clinical diagnosis, vascular risk score (VRS), body mass index (BMI), apolipoprotein ε4 (APOE4), and undernutrition.
Adjusted for clinical diagnosis, VRS, BMI, APOE4, undernutrition, education, occupational complex, annual income, Geriatric Depression Scale (GDS) score, Medical Outcomes Study‐Social Support Survey (MOS‐SSS) score, alcohol intake status, and smoking status.
Aβ, beta‐amyloid; AD‐CM, Alzheimer disease signature cerebral glucose metabolism; AD‐CT, Alzheimer disease signature cortical thickness; CI, confidence interval; HVa, adjusted hippocampal volume; SUVR, standardized uptake value ratio; WBV, whole brain volume.