TABLE 1.
Summary of blood biomarkers of peripheral nerve disease
| Disease | Subtype | Biomarker | Change | Responsive |
|---|---|---|---|---|
| Inflammatory neuropathies | CIDP |
NFL GFAP |
Increased |
Possibly UK |
| GBS | NFL | Increased | UK | |
| Vasculitis |
NFL VEGF |
Yes UK |
||
| CIPN | Oxaliplatin | NFL | Increased | Yes |
| Diabetic neuropathy | Cytokines | Increased | UK | |
| NGF and BDNF | Decreased | UK | ||
| NSE | Increased | UK | ||
| NFL | Increased | UK | ||
| MPZ circ mRNA | Increased | UK | ||
| CMT and Related Disorders | CMT | NFL | Increased | UK |
| CMT | GDF15 | Increased | UK | |
| CMT | NCAM1 | Increased | UK | |
| CMT1A | TMPRSS5 | Increased | UK | |
| CMT1A | MicroRNA | Increased | UK | |
| hATTR | NFL | Increased | Yes | |
| CMT2 | PFN2 | Decreased | UK | |
| CMT2 | GAMT | Decreased | UK |
Abbreviations: BDNF, Brain Derived Neurotrophic Factor; CIDP, Chronic Inflammatory Demyelinating Polyneuropathy; CIPN, Chemotherapy Induced Peripheral Neuropathy; CMT, Charcot–Marie–Tooth disease; GAMT, Guanidinoacetate methyltransferase; GBS, Guillain–Barre Syndrome; GDF15, Growth Differentiation Factor 15; GFAP, Glial Fibrillary Acidic Protein; hATTR, Hereditary Transthyretin Amyloidosis; MPZ, Myelin Protein Zero; NCAM1, Neural Cell Adhesion Molecule 1; NFL, Neurofilament Light Chain; NGF, Nerve Growth Factor; NSE, Neuron‐Specific Enolase; PFN2, Profilin 2; TMPRSS5, Transmembrane Serum Protease 5; UK, Unknown; VEGF, Vascular Endothelial Growth Factor.