. Author manuscript; available in PMC: 2022 Dec 28.

Published in final edited form as: J Thromb Haemost. 2017 May 9;15(6):1086–1094. doi: 10.1111/jth.13698

Table 3.

Hazard ratios (HRs) of coronary heart disease (CHD) and ischemic stroke per standard deviation higher coagulation factor IX antigen level (22%) in REGARDS

	CHD HR (95% CI)	Ischemic stroke HR (95% CI)

Demographic model^*
Entire cohort	1.34 (1.16–1.55)	1.18 (1.03–1.35)
Black	1.63 (1.31–2.04)	1.23 (0.98–1.53)
White	1.17 (0.98–1.41)	1.15 (0.98–1.36)
Race × FIX	0.02	0.66
P-value
Risk factor model^†
Entire cohort	1.19 (1.01–1.40)	1.03 (0.89–1.19)
Black	1.39 (1.10–1.75)	1.00 (0.80–1.25)
White	1.06 (0.86 –1.31)	1.05 (0.88–1.26)
Race × FIX	0.08	0.70
P-value

CI, confidence interval.

Adjusted for age, sex, race, and region. Stroke: adjusted for age, sex, race, region, and age × race.

^†

CHD: adjusted for demographic model + systolic blood pressure, use of antihypertensive medications, diabetes, current smoking, total cholesterol, HDL cholesterol, and use of cholesterol-lowering medications. Stroke: adjusted for demographic model + systolic blood pressure, use of antihypertensive medications, diabetes, current smoking, baseline cardiovascular disease, baseline atrial fibrillation, and baseline left ventricular hypertrophy.