Table 5.

Attenuation of the associations of factor IX antigen with coronary heart disease (CHD) by adjustment for C-reactive protein (CRP) and D-dimer

CHD	FIX HR (95% CI)	FIX + CRP HR (95% CI)	Change in HR by CRP (95% CI)	FIX + D-dimer HR (95% CI)	Change in HR by D-dimer (95% CI)
Entire cohort	1.19 (1.01–1.40)	1.09 (0.92–1.30)	0.10 (0.04–0.18)	1.16 (0.97–1.37)	0.03 (− 0.02 to 0.09)
Black	1.39 (1.10–1.75)	1.27 (0.99–1.64)	0.12 (0.04–0.22)	1.38 (1.08–1.77)	0.01 (− 0.09 to 0.09)
White	1.06 (0.86–1.31)	0.99 (0.80–1.22)	0.07 (0.02–0.16)	1.03 (0.83–1.27)	0.03 (− 0.02 to 0.10)

CI, confidence interval; HR, hazard ratio. FIX antigen was modeled per standard deviation higher level (22%). Analyses were adjusted for: age, sex, race, region, systolic blood pressure, use of antihypertensive medications, diabetes, current smoking, total cholesterol, HDL cholesterol, and cholesterol-lowering medication use. Race-stratified analyses were not adjusted for race.