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. 2022 Dec 14;16:1074304. doi: 10.3389/fncel.2022.1074304

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Copyright © 2022 Dannhäuser, Mrestani, Gundelach, Pauli, Komma, Kollmannsberger, Sauer, Heckmann and Paul.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Unc-13^GFSTF is expressed in the adult and larval central nervous system and at larval neuromuscular junctions (NMJs). (A) Adult central nervous system (CNS) stained with Brp^Nc82 (green) and rabbit α -green fluorescent protein (α-GFP) antibody to visualize Unc-13^GFSTF (magenta). (B) Larval ventral nerve cord (VNC) of a male 3rd instar Drosophila larva stained with the same antibodies as in (A). (C) Co-expression of Brp^Nc82 (green) and Unc-13^GFSTF (magenta) at a 3rd instar larval NMJ on abdominal muscles 6/7 in segment A3. (D) Structured illumination microscopy imaging of a type Ib bouton of a larval NMJ on abdominal muscles 6/7 shows pre- and postsynaptic co-localization of α-horseradish peroxidase (α-HRP) (blue), Unc-13^GFSTF (magenta), and Brp^Nc82 (green, upper panel) or GluRIIA receptor subunits (green, lower panel). Scale bars in (A) and (B) 100 μm, in (C) 20 and 2 μm (inset) and in (D) 1 μm.