Table 5. Relationship of brain pathologies to cognitive function.

Simple regression analysis adjusted for age, sex, education and lewy body pathology.

Pathology	Attention		Memory		Language		Processing speed		Executive function		Global
	β	P value	β	P value	β	P value	β	P value	β	P value	β	P value
Vascular pathology
Atherosclerosis	−0.032	0.434	−0.013	0.76	−0.032	0.44	−0.112	0.006	−0.092	0.023	−0.074	0.07
Arteriosclerosis	−0.081	0.051	−0.078	0.056	−0.103	0.011	−0.077	0.055	−0.072	0.076	−0.098	0.016
Infarcts/lacunes	−0.02	0.626	0.033	0.419	0.012	0.768	−0.063	0.111	−0.064	0.11	−0.032	0.426
Hemorrhages/microbleeds	−0.06	0.199	−0.071	0.078	−0.056	0.161	0.006	0.88	−0.02	0.621	−0.044	0.272
Microinfarcts	0	0.996	0.063	0.123	0.047	0.246	0.043	0.277	0.034	0.392	0.045	0.26
WM rarefarction	0.008	0.839	0.01	0.808	−0.004	0.923	−0.038	0.336	0.014	0.734	0.001	0.985
AD pathology
Neurofibrillary tangles	−0.287	<0.001	−0.41	<0.001	−0.367	<0.001	−0.27	<0.001	−0.305	<0.001	−0.394	<0.001
Neuritic plaque	−0.247	<0.001	−0.44	<0.001	−0.399	<0.001	−0.253	<0.001	−0.307	<0.001	−0.397	<0.001