MitoPark mice were monitored at 2-wk intervals for olfactory deficits from 8–24 weeks of age. n=25 control and n=19 MitoPark mice. A-B, Occupancy plots and quantification of (C-F) time in scented zones are shown. Red arrows indicate scented zones. Olfactory deficits as determined by (A, C, E) social discrimination test (SDT) and (B, D, F) novel scent test (NST) were present as soon as 14 weeks of age in MitoPark mice versus controls. *, p≤0.05; **, p<0.01; ***, p<0.001.