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Effect of the dominant positive mutant of MKK6 on LPS-induced DNA synthesis in CD14-CHO cells. (A) CD14-CHO cells were transfected with a dominant positive mutant of MKK6, and DNA synthesis was determined in the presence or absence of LPS. (B) Phosphorylation of p38 MAP kinase in CD14-CHO cells transfected with a dominant positive mutant of MKK6 was confirmed by immunoblotting.
