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. Author manuscript; available in PMC: 2023 Oct 1.
Published in final edited form as: Adv Ther (Weinh). 2022 Aug 4;5(10):2200130. doi: 10.1002/adtp.202200130

Fig 2. Calibration and simulation results of the CRS model.

Fig 2.

(A–C) Calibration results and simulation using Monte Carlo method to estimate the distribution of IL-6 time series of the population. Black lines show median, color bands show prediction intervals with different probabilities, and dots show clinical observations. Patient number = 17. (D–F) Simulated time series of CAR T-cell and equivalent monocyte number in bone marrow (D), and cytokine release rates in bone marrow (E) and serum (F). Negative release rate in F means clearance of cytokines. (G) Experimental (dot) and simulated (line) time series results of concentrations of different cytokines in serum.