. Author manuscript; available in PMC: 2023 Oct 1.

Published in final edited form as: Adv Ther (Weinh). 2022 Aug 4;5(10):2200130. doi: 10.1002/adtp.202200130

Table 4.

Population-level fitted release rates of various cytokines (molecular level modeling)

Parameter	Description	Unit	Value

μ _T,TNFα	Release rate of TNF-α from CAR T-cells into serum	pg mL⁻¹ day⁻¹(10⁹ cell)⁻¹	0.0004
μ _T,IFNγ	Release rate of IFN-γ from CAR T-cells into serum	pg mL⁻¹ day⁻¹(10⁹ cell)⁻¹	0.0116
μ _T,IL2	Release rate of IL-2 from CAR T-cells into serum	pg mL⁻¹ day⁻¹(10⁹ cell)⁻¹	0.0015
μ _{M, TNFα}	Release rate of TNF-α from monocytes stimulated by tumor lysis into serum	pg mL⁻¹ (10⁹ cell)⁻¹	0.4618
μ _M,IL1	Release rate of IL-1 from monocytes stimulated by tumor lysis into serum	pg mL⁻¹ (10⁹ cell)⁻¹	0.4133
μ _M,IL6	Release rate of IL-6 from monocytes stimulated by tumor lysis into serum	pg mL⁻¹ (10⁹ cell)⁻¹	1.8253
μ _M,IL8	Release rate of IL-8 from monocytes stimulated by tumor lysis into serum	pg mL⁻¹ (10⁹ cell)⁻¹	0.5683
μ _M,IL10	Release rate of IL-10 from monocytes stimulated by tumor lysis into serum	pg mL⁻¹ (10⁹ cell)⁻¹	6.1396
μ _M,IL12	Release rate of IL-12 from monocytes stimulated by tumor lysis into serum	pg mL⁻¹ (10⁹ cell)⁻¹	1.8594