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. Author manuscript; available in PMC: 2023 Aug 1.
Published in final edited form as: Adv Nanobiomed Res. 2022 Jul 19;2(8):2200037. doi: 10.1002/anbr.202200037

Figure 4.

Figure 4.

Pharmacokinetic analysis of data in Figure 3. A) One-compartment analysis of percent-labeled RBCs. B) % MFI based on extrapolation because some of the derivatives did not reach 50% of the initial level. DiI-C18 and DiI-PEG3400Mtz MFI values were best fitted with the two-compartment model; other were fitted with the one-compartment model. For DiI-C18, one of the mice did not produce a good fit. C) Summary of the analysis. Note that for some of the derivatives, the MFI half-life is much longer than the RBC half-life. DiI-C18 and DiI-PEG3400Mtz RBCs showed the longest half-life and the best stability in the membrane. P-value: ****<0.0001; ***<0.001,**<0.01,*0.05; one-way ANOVA with multiple comparisons.