Table 1.

Features of nanobodies compare to conventional antibodies.

a	Nanobodies are able to recognize native epitopes, which are unusual for the classical antibodies.
b	Lesser amount of immunogenicity.
c	High stability and solubility in the harsh environments (denaturing conditions or high temperatures).
d	Small size facilitated to higher tissue penetration.
e	Nanobodies can be produced easily in yeast and bacteria. Its lack the Fc domain (glycan-harboring), and are easy to make than the standard mAbs.
f	Due to the absence of Fc regions, nanobodies have low risk of antibody-dependent enhancement of infection.
g	Life span of nanobodies can be enhanced by adding human albumin or polyethylene glycol.
h	Nanobodies can be used for new immunobiotechnological purposes and are very easy to manipulate.
i	Effortless for the selection by phage display.