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. 2017 May 4;1:PO.16.00007. doi: 10.1200/PO.16.00007

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© 2017 by American Society of Clinical Oncology

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Fig 6. — Glutamine metabolism and model of lactate production in SDHB-deficient human kidney cancer. (A) The ¹⁸F-glutamine positron emission tomography (PET) scan of patient 2. (B) Levels of intracellular metabolites. Relative metabolite levels were measured in SDHB^−/− primary cell cultures after 6 hours of glutamine starvation. Counts are normalized to cell numbers, and results from full complete media are denoted at 1. Error bars indicate standard deviation (n = 3). (C) Measurement of apoptosis. Annexin V staining of apoptotic cells was determined in SDHB^−/− primary cell culture after 72 hours of glutamine deprivation. Error bars indicate standard deviation (n = 3). (D) Model depicts the increased glucose flux and lactate production in SDHB-deficient cancer cells. CoA, coenzyme A; FAD, flavin adenine dinucleotide; TCA, tricarboxylic acid.