Table 3. Studies examining the association between infertility and IPAA.
| Author | Year of publication | Study design | Diagnosis | No IPAA INF/FER |
No IPAA infertility rate (%) | IPAA INF/FER |
IPAA infertility rate (%) | RR |
|---|---|---|---|---|---|---|---|---|
| Gorgun et al 55 | 2004 | RC | UC, FAP | 48/79 | 38 | 76/59 | 56 | < 0.001 a |
| Waljee et al 56 | 2006 | MA | UC | 60/551 | 14.6 | 231/250 | 48 | 3.17 |
| Rajaratnam et al 57 | 2011 | MA | UC, FAP | 112/448 | 20 | 289/169 | 63 | 3.91 |
| Tulchinsky et al 58 | 2013 | RC | UC | 0/26 | 0 | 10/17 | 37 | 0.0006 a |
| Sriranganathan et al 59 | 2022 | MA | UC | 105/688 | 13.3 | 344/458 | 43.0 | 4.17 |
Abbreviations: FAP, familial adenomatous polyposis; FER, fertile; INF, infertile; IPAA, ileal pouch-anal anastomosis; MA, meta-analysis; RC, retrospective cohort study; RR, relative risk; UC, ulcerative colitis.
a
Indicates calculated p -value. The relative risk was not reported in these studies.