Table 2.
Immunological features of autoantibodies against PLIN1
| Code | AGL variety | Autoantibody isotype | IgG autoantibody subclass | Autoantibody light chains | IgG autoantibody titers (AU/mL) | IgM autoantibody titers (AU/mL) |
|---|---|---|---|---|---|---|
| AGL1 | Autoimmune | IgG, IgM | IgG1, IgG2, IgG3 | κ | 323.2 | 1,513.4 |
| AGL2 | Autoimmune | IgG | IgG1 | κ | 110.7 | — |
| AGL3 | Autoimmune | IgG, IgM | IgG1 | κ+λ | 1,000* | 1,000* |
| AGL9 | Autoimmune | IgG | IgG3 | κ+λ | 7,998.2 | — |
| AGL10 | Panniculitis plus autoimmune | IgG | IgG3 | κ+λ | 102 | — |
| AGL11 | Panniculitis | IgG | IgG1, IgG2, IgG3 | κ | 9,763.6 | — |
| AGL13 | Panniculitis plus autoimmune | IgG | IgG1, IgG4 | κ+λ | 523.1 | — |
| AGL14 | Panniculitis | IgG | IgG3 | κ+λ | 72.1 | |
| AGL16 | Panniculitis plus autoimmune | IgG | IgG1, IgG2, IgG3 | κ+λ | 348.2 | — |
| AGL18 | Autoimmune | IgG | IgG1, IgG2, IgG3 | κ+λ | 1,026.4 | — |
| AGL20 | Autoimmune | IgG | IgG1, IgG2 | κ+λ | 1,080.3 | |
| AGL21 | Autoimmune | IgM | — | κ+λ | — | 1,386.5 |
| AGL23 | Panniculitis plus autoimmune | IgG | IgG1, IgG3 | κ+λ | 1,047.1 | — |
| AGL24 | Autoimmune | IgG | IgG1 | κ+λ | 1,356.1 | |
| AGL28 | Autoimmune | IgG | IgG3 | κ+λ | 421.4 | |
| AGL32 | Panniculitis | IgG, IgM | IgG1, IgG3 | κ+λ | 4,039.1 | 4,599.7 |
| AGL33 | Panniculitis plus autoimmune | IgG | IgG1, IgG3 | κ+λ | 33,640 | — |
| AGL37 | Panniculitis plus autoimmune | IgG, IgM | IgG1, IgG3 | κ | 909.8 | 4,929.7 |
| AGL38 | Autoimmune | IgG | IgG1 | κ | 4,842.7 | — |
| AGL39 | Panniculitis plus autoimmune | IgG, IgM | IgG1 | κ+λ | 198,200 | 3,899.7 |
*
A reference patient serum (AGL3) was used to calibrate the assay and to calculate anti-PLIN1 autoantibody titers in AU per milliliter.