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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Arthritis Rheumatol. 2022 Nov 25;75(1):53–63. doi: 10.1002/art.42288

Figure 5. Bile acid levels differ significantly between PsNP and PsP patients.

Figure 5.

A) Differential abundance of primary and secondary bile acids in samples collected from Ps and PsA patients. Serum samples were analyzed with an unbiased approach and detected primary and secondary bile acid levels were compared between Ps patients who did (PsP, n=13) or did not progress (PsNP, n=21). Samples collected before or after the onset of arthritis from 13 PsP patients were compared with 21 PsNP. Differentially abundant primary and secondary bile acids achieving statistical significance (p<0.05) are shown. In addition, metabolites that are significant after FDR correction (Storey q value <0.05) are further marked with an asterisk (*); B) schematic diagram depicting synthesis of primary and secondary bile acids from cholesterol in the liver and microbial metabolism in the gut.