Table 2-.

Treatment-related and treatment-emergent adverse events experienced by ≥ 10% patients on selinexor and weekly paclitaxel

Adverse Event	Treatment-related adverse events n, (%)		Treatment-emergent adverse events n, (%)
	All grades	G3/G4	All grades	G3/G4
Anemia	26 (74)	11 (31)	29 (83)	11 (31)
Nausea	20 (57)	1 (3)	22 (63)	1 (3)
Leukopenia	18 (51)	6 (17)	21 (60)	6 (17)
Fatigue	18 (51)	3 (9)	20 (57)	4 (11)
Neutropenia	17 (49)	16 (46)	18 (51)	16 (46)
Thrombocytopenia	16 (46)	2 (6)	17 (49)	3 (9)
Hyponatremia	12 (34)	3 (9)	19 (54)	6 (17)
Vomiting	11 (31)	1 (3)	14 (40)	2 (6)
Aspartate aminotransferase increased	8 (23)	1 (3)	11 (31)	1 (3)
Alanine aminotransferase increased	7 (20)	1 (3)	10 (29)	1(3)
Alkaline phosphatase increased	6 (17)	0 (0)	7 (20)	0 (0)
Peripheral sensory neuropathy	6 (17)	2 (6)	7 (20)	2 (6)
Mucositis - oral	5 (14)	0 (0)	6 (17)	0 (0)
Anorexia	4 (11)	0 (0)	6 (17)	0 (0)
Blurred vision	4 (11)	0 (0)	4 (11)	0 (0)
Diarrhea	4 (11)	1 (3)	12 (34)	1 (3)
Lymphopenia	4 (11)	2 (6)	6 (17)	3 (9)
Dyspnea	2 (6)	0 (0)	12 (34)	1 (3)
Abdominal Pain	1 (3)	0 (0)	10 (29)	3 (9)
Edema – limbs	2 (6)	0 (0)	9 (26)	1 (3)
Constipation	2 (6)	0 (0)	8 (23)	0 (0)
Hypokalemia	1 (3)	0 (0)	8 (23)	0 (0)
Hypoalbuminemia	2 (6)	0 (0)	7 (20)	0 (0)
Cough	0 (0)	0 (0)	6 (17)	0 (0)
Creatinine increased	1 (3)	1 (3)	5 (14)	1 (3)
Hypophosphatemia	2 (6)	0 (0)	5 (14)	1 (3)
Abdominal distention	1 (3)	0 (0)	5 (14)	0 (0)
Dizziness	3 (9)	0 (0)	5 (14)	0 (0)
Headache	0 (0)	0 (0)	5 (14)	0 (0)
Thromboembolic event	1 (3)	1 (3)	4 (11)	2 (6)
Hyperuricemia	1 (3)	1 (3)	4 (11)	1 (3)
Fever	0 (0)	0 (0)	4 (11)	0 (0)
Hyperkalemia	2 (6)	0 (0)	4 (11)	0 (0)
Syncope	2 (6)	2 (6)	2 (6)	2 (6)
CPK increased	1 (3)	1 (3)	2 (6)	1 (3)
Sepsis	1 (3)	1 (3)	1 (3)	1 (3)
Stroke	1 (3)	1 (3)	1 (3)	1 (3)
Colonic Fistula	0 (0)	0 (0)	1 (3)	1 (3)
Hypertension	0 (0)	0 (0)	1 (3)	1 (3)
Non-cardiac chest pain	0 (0)	0 (0)	1 (3)	1 (3)
Pain	0 (0)	0 (0)	1 (3)	1 (3)
Small intestinal obstruction	0 (0)	0 (0)	1 (3)	1 (3)
Thrombotic thrombocytopenia purpura	0 (0)	0 (0)	1 (3)	1 (3)